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NAD Injection Protocol

A NAD injection protocol is a structured treatment plan that outlines the dosage, frequency, and administration schedule for NAD+ injectable therapy under licensed medical supervision. Because NAD therapy involves compounded injectable medications, a defined protocol is required before treatment begins — typically established during a telehealth consultation or medical intake process. The specific details vary depending on individual health goals, baseline NAD levels, and provider guidelines, but most programs are organized around an initial loading phase followed by a structured maintenance schedule. Understanding how treatment is structured helps you ask the right questions when comparing telehealth programs and sets realistic expectations for what supervised care actually involves. For foundational context on how NAD functions in the body, review our What is NAD guide.
Licensed provider reviewing a NAD injection protocol and structured treatment schedule

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What a Standard NAD Injection Protocol Includes

A structured treatment plan typically covers four core components: starting dose, injection frequency, titration schedule, and total program duration. Starting doses in most clinician-guided protocols range from 100 mg to 250 mg per injection, with gradual increases based on individual tolerance and response. Frequency varies by program — some protocols call for daily injections during an initial loading phase, while others begin with two to three injections per week. Titration is a key part of any well-designed program, allowing providers to increase milligram doses incrementally rather than starting at full therapeutic strength. Program duration depends on the treatment goal, whether that is energy support, metabolic health, or long-term cellular maintenance. For a detailed breakdown of milligram ranges used across different program tiers, review our NAD injection dosage chart.

Loading Phase vs Maintenance Phase in a NAD Injection Protocol

Most structured programs are divided into two distinct phases — a loading phase and a maintenance phase. The loading phase typically involves more frequent injections over a defined period, often two to four weeks, with the goal of replenishing depleted NAD+ levels and establishing a therapeutic baseline. Once that baseline is achieved, treatment transitions into a maintenance phase where injection frequency is reduced — commonly to weekly or biweekly sessions — to sustain NAD+ levels rather than rebuild them. How long each phase lasts depends on individual response, dosing strength, and provider assessment. Understanding how these two phases work together helps set realistic expectations for both early results and long-term outcomes. For more on how treatment duration and results develop over time, review our how long do NAD injections last guide.

How NAD Injection Protocols Vary by Treatment Goal

Treatment structure shifts depending on what the patient is trying to achieve. Individuals focused on energy support and cognitive performance may follow a more aggressive loading schedule with higher starting doses, while those using NAD therapy as part of a long-term longevity strategy may begin with lower doses on a less frequent schedule and prioritize the maintenance phase. Metabolic health programs sometimes pair injectable NAD therapy with lifestyle modifications and additional clinical monitoring. Age, baseline health, existing conditions, and current medications all factor into how a provider structures and adjusts a program over time. This is why a thorough medical intake is a non-negotiable part of any legitimate NAD injection protocol before treatment is issued. To understand what outcomes are typically reported across these different program structures, review our full NAD injection results guide. To explore how NAD therapy is applied across different health goals, review our NAD injection benefits guide.

Why Your NAD Injection Protocol Must Come From a Licensed Provider

A NAD injection protocol sourced from anywhere other than a licensed healthcare provider carries significant risk. Because NAD+ injections are compounded medications, the dosing, titration schedule, and administration instructions within a protocol must be tailored to an individual's medical history and health status — not copied from a generic template or online forum. Reputable telehealth programs require a full medical intake before issuing any NAD injection protocol, ensuring that dose strength and frequency are appropriate for the patient and that ongoing adjustments can be made based on response. Pharmacy sourcing is another critical factor — medications used in a legitimate protocol should come from licensed U.S. compounding pharmacies that follow established sterility and quality standards. For a full breakdown of what makes a supervised program clinically acceptable, review our are NAD injections safe guide. To understand what the prescription process looks like before a protocol is issued, review our NAD injection prescription guide.

Frequently Asked Questions About NAD Injection Protocol

A NAD injection protocol is a structured treatment plan issued by a licensed provider that outlines your starting dose, injection frequency, titration schedule, and total program duration. It is required before beginning any injectable NAD therapy program.

Most NAD injection protocols include an initial loading phase of two to four weeks followed by an ongoing maintenance phase. Total program length depends on individual health goals and how the body responds to treatment.

Yes — many telehealth programs are designed around at-home administration. Your NAD injection protocol will include specific instructions on dosing, site selection, injection technique, and how to track your response between provider check-ins.

A licensed provider monitors your response and adjusts the protocol based on tolerance, progress, and any side effects. Titration — gradually increasing the dose — is a standard part of most NAD injection protocol structures during the loading phase.

No. A NAD injection protocol is individualized based on health history, treatment goals, baseline NAD levels, and provider assessment. Programs focused on energy, longevity, or metabolic health will each follow a different protocol structure.

Start Your NAD Injection Protocol With the Right Program
Following a NAD injection protocol correctly begins with choosing a provider who builds one around your specific health needs rather than a generic template. The structure of your protocol — dosing strength, phase timing, and adjustment schedule — directly influences how consistently your body responds to treatment over time. Working with a licensed telehealth provider ensures your NAD injection protocol is monitored, adjustable, and backed by clinical oversight from day one. If you are ready to compare programs that offer fully structured protocols with medical supervision and home delivery, review our best NAD injections at home guide.
🔒 Valid prescription for NAD or NAD+ injections from a licensed provider required.


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