NAD+ Injection Dosage Guide & Chart
How much, how often, and where — the practical breakdown of structured NAD+ dosing, from starting dose through maintenance.
How NAD+ Dosing Is Structured
NAD+ injection dosage is measured in milligrams per session and structured within a clinician-guided protocol — it is never self-directed. (New to NAD+? Start with what NAD+ actually does in the body.) After a medical screening that reviews health history, treatment goals, and individual tolerance, your provider establishes a starting dose and a plan for adjusting it over time.
Most programs are organized around two phases:
Loading phase. A more frequent injection schedule — typically two to three times per week — over an initial two-to-four-week period, designed to rapidly replenish depleted NAD+ stores and establish a therapeutic baseline.
Maintenance phase. Once baseline levels are restored, frequency drops to once or twice weekly, or even biweekly to monthly for long-term upkeep, sustaining results without the cost or commitment of the loading schedule.
System Labs NAD+ Injections
Clinical-grade NAD+ reviewed by a licensed clinician and sourced from regulated U.S. pharmacies — no clinic visits or IV lounge pricing. Structured dosing with ongoing provider support and free 2-day shipping.
EnhanceMD NAD+ Injections
Pharmaceutical-grade NAD+ delivered via subcutaneous injection for maximum bioavailability and rapid cellular energy support. Includes ongoing provider access and ships direct with full onboarding support.
Embody NAD+ Injections
Physician-reviewed NAD+ injections sourced from a US-certified pharmacy, formulated for fast-acting energy and mental clarity support. Includes 1:1 medical guidance and free 2-day delivery.
Dosage Chart by Tier
| Tier | Dose / Injection | Frequency | Best For |
|---|---|---|---|
| Starting / Low | 50–250 mg | 2–3x/week | New users, general wellness |
| Standard | 250–500 mg | 1–3x/week | Most users — energy, cognitive, metabolic goals |
| High Dose | 500–1000 mg | 1x/week (loading) | Significant depletion, intensive protocols |
| Maintenance | 100–500 mg | Biweekly–monthly | Sustaining results post-loading |
These ranges are general reference points. Actual dosing is always determined by a licensed provider based on individual health evaluation. For a full breakdown of how these ranges translate to a daily average, see our NAD injection dosage per day guide.
What "daily dose" actually means in practice: most programs are not dosed literally every day. Someone injecting 500mg three times per week is averaging roughly 214mg per day of effective NAD+ — concentrated into three sessions rather than spread evenly.
What Determines Your Dosage
Baseline depletion. More severe depletion often calls for a higher starting dose during loading.
Treatment goal. Chronic fatigue or brain fog recovery often requires higher doses than longevity-focused maintenance use.
Body weight and metabolism. Faster metabolic rates may require more frequent dosing to maintain elevated NAD+ between injections.
Treatment phase. Loading is always dosed more aggressively than maintenance.
Underdosing vs. overdosing. Underdosing is the most common reason people report disappointing results. Overdosing isn't associated with serious toxicity, but rapid high doses can cause temporary flushing, nausea, or headache — which is why provider-guided titration produces the most consistent results. See our full benefits and side effects breakdown for more detail.
Where & How to Inject
The most common sites for subcutaneous NAD+ injection are the abdomen, outer thigh, and upper arm — see our full injection site guide for detailed technique and rotation tips. The abdomen is generally preferred for self-injection due to its larger surface area. Rotating between sites is important — repeated injection into the same spot can cause tissue irritation or bruising over time.
Basic self-injection steps:
- Wash hands and clean the injection site with an alcohol swab; let it dry completely
- Draw the prescribed amount, removing any air bubbles
- Pinch the skin gently and insert the needle at the angle specified by your provider
- Inject slowly, withdraw, and apply light pressure with a clean swab
- Dispose of the needle in an approved sharps container — never reuse
How Long Results Last
For most people, the noticeable effects of a single injection last roughly 3 to 7 days, with some reporting benefits up to two weeks depending on dose. Higher doses (500–1000mg) tend to produce longer-lasting effects than lower starting doses.
Lifestyle factors matter too: high stress, poor sleep, and inadequate nutrition can accelerate NAD+ depletion and shorten how long each dose's benefits last. For a closer look at what the research actually shows, see our evidence and safety guide.